Diego Ricardo Muñoz Cendales

GRUPOS DE INVESTIGACIÓN: PRODUCTOS NATURALES U.D.C.A

LÍNEAS DE INVESTIGACIÓN:   Química Medicinal, Productos Naturales, Modelado Molecular, Bioprospección de Agentes terapéuticos.

FACULTAD:  Ciencias

CATEGORÍA COLCIENCIAS:    

NIVEL DE FORMACIÓN: Doctorado

Químico, MSc en Química, PhD en Química. Mi trabajo de investigación está enfocado en la búsqueda e identificación de compuestos naturales que puedan inducir muerte celular en diferentes líneas celulares de cáncer, así como la determinación de sus mecanismos de accion al interior de las céululas. Investigación en las áreas de:

  • Productos Naturales Bioactivos.
  • Bioprospección de agentes terapéuticos.
  • Química Medicinal.
  • Modelado Molecular.

PRODUCTOS DESTACADOS

XIAP as a Target of New Small Organic Natural Molecules Inducing Human Cancer Cell Death
Fecha de publicación: 09/10/2019

Herein we wish to report the discovery and chemical/biological characterisation of novel natural small compounds from Piper genus. Furthermore, a deeper insight into their cell death mechanism in human cells provides a proof-of-concept study of their pharmaceutical potential as antagonists of XIAP that may open important insights on XIAP as a suitable turning point for multiple cellular pathways.


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Metabolic Profiling of the Soft Coral Erythropodium caribaeorum (Alcyonacea: Anthothelidae) from the Colombian Caribbean Reveals Different Chemotypes
Fecha de publicación: 01/01/2020

In this work we characterized the diterpene diversity in samples from E. caribaeorum collected at three geographically distinct locations of the Colombian Caribbean Sea—Santa Marta, Islas del Rosario, and Providencia Island. We used metabolic profiling tools such as LC-MS, as well as the isolation and characterization of the main compounds of each chemotype. Additionally, we evaluated the cytotoxic activity of the isolated compounds against human cancer cell lines in order to contribute to the pharmacological evaluation of the compounds produced by this soft coral.


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In vitro anticancer screening of Colombian plants from Piper genus (Piperaceae)
Fecha de publicación: 30/09/2018

The present study investigated the in vitro cytotoxic effect of 28 ethanolic extracts, from 16 different Colombian Piper spp. against a panel of three human cancer cell lines. In order to explore the cytotoxic compounds, the chromatographic ultra-high performance liquid chromatography (UHPLC) profile of leaves, flowers and wood for the most active specie are presented. The majority component of the extracts was isolated, identified as an alkenylphenol and showed highly cytotoxicity activity.


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Cytotoxic compounds from plant sources and their relationship with inhibitor of apoptosis proteins
Fecha de publicación: 01/09/2016

The purpose of the current article is to discuss the mechanism of action of bioactive phytochemicals against cancer. The most promising therapeutic targets are presented such as the inhibitor of apoptosis proteins (IAP), as well as some bioactive small molecules of pharmacological interest and high specificity against cancer cells.


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Antioxidant, Antitubercular and Cytotoxic Activities of Piper imperiale
Fecha de publicación: 28/03/2012

To our knowledge, only a few investigations have been carried out on Piper imperiale and, as this species is traditionally used by local healers, it is necessary to link chemical compositions to biological effects. This study aims to investigate the total phenol content and the relation of the phenolic composition with antioxidant, antibacterial and cytotoxic activities of P. imperiale.


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