GRUPOS DE INVESTIGACIÓN: CIENCIA ANIMAL

LÍNEAS DE INVESTIGACIÓN:   Genética Cuantitativa; Modelación y Estadística; Selección Genómica; Genética de Poblaciones.

FACULTAD:  Ciencias Agropecuarias

CATEGORÍA COLCIENCIAS:    

NIVEL DE FORMACIÓN: Doctorado

Formación profesional en Zootecnia, Doctor en Ciencias Animales con énfasis en genética y biomodelación animal. Docente Investigador del grupo de investigación Ciencia Animal en la Facultad de Ciencias Agropecuarias U.D.C.A. Investigación en metodologías genómicas y genética cuantitativa para programas de mejoramiento genético y genética de poblaciones en especies domésticas. Docencia en los cursos de genética, mejoramiento genético, sistemas de producción bovina en los programas de Zootecnia, Medicina Veterinaria y Medicina Veterinaria Zootecnia y especialización de producción animal. Consultoría y asesoría a la asociación de criadores de ganado Simmental y Simbrah de Colombia (Asosimmental) a través de análisis de variabilidad genética, patrones de ancestría, evaluación genética con inclusión de información genómica y desarrollo de índices de selección soportado en metodologías bioeconómicas para optimizar el progreso genético y económico de características asociadas a producción de carne y leche.

PRODUCTOS DESTACADOS

Population structure and genetic diversity in ColombianSimmental cattle
Fecha de publicación: 19/11/2019

A vital requirement to design and implement a breeding program is to know the structure and genetic diversity of a population.The aim of this study was to characterize population structure and genetic diversity of the Colombian Simmental cattle. Thepedigree file included 27,985 animals born from 1975 to 2017. The level of genetic diversity and breed structure was evaluatedthrough probabilities of gene origin expressed via effective number of founders, ancestors and founders genomes. The inbreedingrates and the degree of genetic connectivity were estimated using a regression analysis and a genetic drift variance analysis,respectively. The lowest effective number of founders and ancestors were 50 and 38 by year, respectively. The average inbreedingby year of birth decreased from 5.06% in 1980 to 2.25% in 2017. The dairy line genetic contributions in the overall populationincreased significantly in the last 37 years, and the beef line contribution decreased. Regarding the genetic connectivity,Colombian regions (administrative divisions) with the largest cattle population had higher values. The results indicate that theavailability of European and North American bulls contributes to genetic diversity by increasing the effective number of foundersover time in the Colombian Simmental cattle population. However, the intensive use of relatively few founders causes anunbalanced genetic contribution and the loss of genetic diversity by gene pool erosion.


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Population structure and genetic diversity in Colombian Simmental cattle
Fecha de publicación: 19/11/2019

A vital requirement to design and implement a breeding program is to know the structure and genetic diversity of a population. The aim of this study was to characterize population structure and genetic diversity of the Colombian Simmental cattle. The pedigree file included 27,985 animals born from 1975 to 2017. The level of genetic diversity and breed structure was evaluated through probabilities of gene origin expressed via effective number of founders, ancestors and founders genomes. The inbreeding rates and the degree of genetic connectivity were estimated using a regression analysis and a genetic drift variance analysis, respectively. The lowest effective number of founders and ancestors were 50 and 38 by year, respectively. The average inbreeding by year of birth decreased from 5.06% in 1980 to 2.25% in 2017. The dairy line genetic contributions in the overall population increased significantly in the last 37 years, and the beef line contribution decreased. Regarding the genetic connectivity, Colombian regions (administrative divisions) with the largest cattle population had higher values. The results indicate that the availability of European and North American bulls contributes to genetic diversity by increasing the effective number of founders over time in the Colombian Simmental cattle population. However, the intensive use of relatively few founders causes an unbalanced genetic contribution and the loss of genetic diversity by gene pool erosion.


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Molecular characterization of Cryptosporidium parvum and Cryptosporidium hominis GP60 subtypes worldwide
Fecha de publicación: 01/09/2017

Cryptosporidium is a zoonotic parasite very important in animal health as well as in public health. It is because this is one of the main causes of diarrhea in children, calves, lambs and other variety of youth mammalians in a lot of countries. The globalization has enabled the exchange of biological material in different regions worldwide, encouraging the spread of diseases and exposure to these biological agents to different environmental conditions, inducing adaptation through genetic changes. Based in the polymorphism of the gene for GP60, this review intended to present the distribution of Cryptosporidium parvum and Cryptosporidium hominis in humans and calves worldwide. The subtype that affects cattle more frequently corresponds to IIaA15G2R; while the subtype most frequently isolated from human samples is IaA19G2.


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Molecular characterization of Cryptosporidium parvum and Cryptosporidium hominis GP60 subtypes worldwide
Fecha de publicación: 03/09/2017

Cryptosporidium is a zoonotic parasite very important in animal health as well as in public health.  It is because this is one of the main causes of diarrhea in children, calves, lambs and other variety of youth mammalians in a lot of countries. The globalization has enabled the exchange of biological material in different regions worldwide, encouraging the spread of diseases and exposure to these biological agents to different environmental conditions, inducing adaptation through genetic changes. Based in the polymorphism of the gene for GP60, this review intended to present the distribution of Cryptosporidium parvum and Cryptosporidium hominis in humans and calves worldwide. The subtype that affects cattle more frequently corresponds to IIaA15G2R; while the subtype most frequently isolated from human samples is IaA19G2.


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Linkage disequilibrium, population stratification and patterns of ancestry in Simmental cattle
Fecha de publicación: 15/04/2020

The massive use of a few bulls in artificial insemination programs affects the structure and genetic composition of a population. The aim of this study was to estimate the genetic diversity, population stratification, patterns of ancestry and linkage disequilibrium in Simmental cattle. A sample of 233 genotyped animals with 30.106 single nucleotide polymorphism (SNP) was used. Principal components analysis and probabilistic assignments were performed to estimate patterns of genetic subdivision and ancestry. Linkage disequilibrium was estimated as the square of the genetic correlation coefficient between SNP ́s. The principal components analysis did not show genetic subdivision patterns within the population. However, the analysis of ancestry showed a genetic subdivision of three groups. A value of 0.3 for linkage disequilibrium was found at a distance of 33 kb. Results indicate that imported genetic material from populations with different breeding goals and selection criteria could contribute to changes on genetic structure

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